Molecular evidence for the ancient origin of the ribosomal protection protein that mediates tetracycline resistance in bacteria.
作者： Takeshi Kobayashi , Lisa Nonaka , Fumito Maruyama , Satoru Suzuki
DOI: 10.1007/S00239-007-9006-Z
关键词:
摘要: The ribosomal protection proteins (RPPs) mediate the resistance to tetracycline (TC) in Gram-positive and Gram-negative bacteria. RPPs display sequence similarity translation elongation factors, EF-G/EF-2 EF-Tu/EF-1α. To determine evolutionary origin of RPPs, we constructed a composite phylogenetic tree This includes two universal trees for EF-Tu/EF-1α, which form clusters corresponding respective groups from three superkingdoms. cluster was placed at point between EF-Tu/EF-1α clusters. branch length (substitutions/site) node RPP primary divergence statistically shorter than that this cluster. indicates derived through duplication ancient GTPase before Furthermore, suggests RPPs’ extant function occurred streptomycetes include TC-producing strains. Therefore, evolved independent presence TCs serve other antibiotic resistance. may provide against chemical substances environment.
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