Growth/differentiation factor-5 induces angiogenesis in vivo.
作者： Hidetoshi Yamashita , Akira Shimizu , Mitsuyasu Kato , Hideki Nishitoh , Hidenori Ichijo
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摘要: Bone morphogenetic proteins (BMPs) are multifunctional cytokines, which induce bone and cartilage formation and exert various other effects on many tissues. Since angiogenesis is involved in the bone formation process, certain members in the BMP family may induce angiogenesis. We examined thein vivoangiogenic activity of BMP family members, ie, growth/differentiation factor (GDF)-5 and BMP-2. GDF-5 induced angiogenesis in both chick chorioallantoic membrane and rabbit cornea assays. In contrast, BMP-2 did not induce …
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