Canine models of bone marrow transplantation.

摘要: Progress in experimental bone marrow transplantation dogs has provided for the direct transfer of research data to clinical setting and therapeutic application grafting a variety human diseases. Animal models total body irradiation, engraftment graft-versus-host disease are still needed solve existing problems transplantation. Therefore, work various canine model systems continues be interest. Pet with spontaneously occurring lymphomas used study parameters necessary applying technique transplanting their own (autologous), conjunction high dose radiation and/or chemotherapy, patients cancer. A major consideration successful donor (allogeneic) is overcoming histocompatibility barriers assure prevention disease, limiting aspect Chemicals, radiation, radiotherapeutic techniques, antisera monoclonal antibodies have been continue developed laboratory bred dogs. These approaches suppress immune system either nonspecifically by ablation reactive tissue, or specifically affecting certain types cells. Parameters such as effectiveness (engraftment disease), reconstitution undesirable side affects long-term survivors all determine whether new technology can transferred from preclinical studies protocols.