Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
作者： Arvin C. Dar , Tirtha K. Das , Kevan M. Shokat , Ross L. Cagan
DOI: 10.1038/NATURE11127
关键词:
摘要: Using Ret-driven models of multiple endocrine neoplasia, it is shown that optimal kinase inhibition must aim to target an ideal spectrum tumour-relevant kinases while avoiding ‘anti-targets’ cause unwanted toxicity.
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