Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo
作者： Tim Czopka , Charles ffrench-Constant , David A. Lyons
DOI: 10.1016/J.DEVCEL.2013.05.013
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摘要: The number of myelin sheaths made by individual oligodendrocytes regulates the extent myelination, which profoundly affects central nervous system function. It remains unknown when, during their life, can regulate sheath in vivo. We show, using live imaging in zebrafish, that make new myelin sheaths a period just 5 hr, with regulation after this time limited to occasional retractions. also show activation and reduction Fyn kinase increases decreases per cell, respectively. Interestingly, these generate within same period, despite having vastly different extents myelination. Our data demonstrate restricted window relative lifetime oligodendrocyte, formation occurs is determined.
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