Recent advances in simultaneous analysis of bisphenol A and its conjugates in human matrices: Exposure biomarker perspectives.

摘要: Human exposures to bisphenol A (BPA) has attained considerable global health attention and represents one of the leading environmental contaminants with potential adverse effects including endocrine disruption. Current practice measuring exposure BPA includes measurement unconjugated (aglycone) total (both conjugated unconjugated) BPA; difference between two measurements leads estimation forms. However, as end analyte inaccurate estimates from interferences background sources during sample collection analysis. glucuronides (BPAG) sulfates (BPAS) represent better candidates for biomarkers exposure, since they require in vivo metabolism are not prone external contamination. In this work, primary focus was review current state art analytical methods available quantitate conjugates. The entire procedure simultaneous extraction detection aglycone conjugates is covered, pre-treatment, extraction, separation, ionization, detection. Solid phase coupled liquid chromatograph tandem mass spectrometer analysis provides most sensitive quantification Discussed herein applications human assessment studies. Measuring these only recently become analytically feasible there limitations challenges overcome biomonitoring