A genetic basis for atrophy: dominant non-responsiveness and helicobacter induced gastritis in F1 hybrid mice

摘要: BACKGROUND—The importance of host factors in helicobacter induced gastritis has been shown animal models. Infection most mouse strains with Helicobacter felis results a functional atrophic gastritis, while other remain free. AIMS—To investigate these further by using genetic crosses responder and non-responder mice. METHODS—F1 hybrids the CBA/Ca strain three mice known to develop H were infected for months felis. Gastritis was assessed histopathology serum antibody responses ELISA. RESULTS—Infection F1 little or no gastritis. Analyses revealed virtually undetectable anti-helicobacter levels despite colonisation high numbers In contrast, infection responsive significant humoral immune response. CONCLUSIONS—The non-responsiveness is dominantly inherited. The lack CBA their offspring probably due active suppression response normally mounted against Investigation mechanisms will provide important insights relevant induction gastric atrophy cancer humans. Keywords: helicobacter; non-responsiveness; gastritis; hybrid;