THE OPIOID CONTROL OF LH AND FSH RELEASE: EFFECTS OF A MET‐ENKEPHALIN ANALOGUE AND NALOXONE
作者： A. GROSSMAN , P. J. A. MOULT , R. C. GAILLARD , G. DELITALA , W. D. TOFF
DOI: 10.1111/J.1365-2265.1981.TB00363.X
关键词:
摘要: SUMMARY The effect of a long-acting analogue met-enkephalin (DAMME) and naloxone on gonadotrophin secretion has been investigated in man. In menopausal women DAMME induced progressive fall LH to approximately 60% basal levels at 3 h, which was blocked by naloxone; there smaller FSH that did not attain statistical significance. However, the LHRH-induced rise young male volunteers unaffected pretreatment with high-dose infusion. Naloxone infusion female normal subjects produced significant both FSH. Long-term appeared increase rate, possibly amplitude, pulsatility. These results suggest met-enkephalin-like opioid peptides exert tonic inhibitory control release sexes. This is most likely be level hypothalamus, involves modulation pulsatile LHRH release.
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