Lowly expressed ribosomal protein s19 in the feces of patients with colorectal cancer.
作者： Chih-Cheng Chien , Tien-Chien Tu , Chi-Jung Huang , Shung-Haur Yang , Chia-Long Lee
DOI: 10.5402/2012/394545
关键词:
摘要: Colorectal cancer (CRC) has become one of the most common fatal cancers. CRC tumorigenesis is a complex process involving multiple genetic changes to several sequential mutations or molecular alterations. P53 significant genes; its account for more than half all CRC. Therefore, understanding cellular genes that are directly indirectly related p53 particularly crucial investigating tumorigenesis. In this study, p53-related ribosomal protein, protein S19 (RPS19), obtained from feces patients evaluated by using specifically quantitative real-time PCR and knocked down in colonic cell line gene silencing. This study found with higher expressions RPS19 their had better prognosis consistent BAX cells. conclusion, potential mechanism possibly involves apoptosis through BAX/p53 pathway, levels fecal may function as prognostic predictor patients.
hindawi.com参考文章(43)
M Fukayama, R Kikuchi-Yanoshita, Y Maeda, M Seki, M Konishi, T Mori, M Koike, H Iino, K Tanaka, S Ito, Genetic Changes of Both p53 Alleles Associated with the Conversion from Colorectal Adenoma to Early Carcinoma in Familial Adenomatous Polyposis and Non-Familial Adenomatous Polyposis Patients Cancer Research. ,vol. 52, pp. 3965- 3971 ,(1992)
Hui Wang, Li-Na Zhao, Kai-Zong Li, Rui Ling, Xiao-Jun Li, Ling Wang, Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer BMC Cancer. ,vol. 6, pp. 91- 91 ,(2006) , 10.1186/1471-2407-6-91
Nadia Danilova, Kathleen M. Sakamoto, Shuo Lin, Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family. Blood. ,vol. 112, pp. 5228- 5237 ,(2008) , 10.1182/BLOOD-2008-01-132290
Ruey-Neng Yang, Shung-Haur Yang, Chun-Chao Chang, Chih-Cheng Chien, Shiann Pan, Chi-Jung Huang, Upregulation of Fecal Cytokeratin 19 Is Associated with Prognosis in Older Colorectal Cancer Patients Genetic Testing and Molecular Biomarkers. ,vol. 14, pp. 703- 708 ,(2010) , 10.1089/GTMB.2010.0047
Linda Panić, Sanda Tamarut, Melanie Sticker-Jantscheff, Martina Barkić, Davor Solter, Miljana Uzelac, Kristina Grabušić, Siniša Volarević, Ribosomal Protein S6 Gene Haploinsufficiency Is Associated with Activation of a p53-Dependent Checkpoint during Gastrulation Molecular and Cellular Biology. ,vol. 26, pp. 8880- 8891 ,(2006) , 10.1128/MCB.00751-06
C.-J Huang, C.-C. Chien, S.-H. Yang, C.-C. Chang, H.-L. Sun, Y.-C. Cheng, C.-C. Liu, S.-C. Lin, C.-M. Lin, Faecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer. Journal of Cellular and Molecular Medicine. ,vol. 12, pp. 1936- 1943 ,(2008) , 10.1111/J.1582-4934.2008.00253.X
Masatoshi Takagi, Michael J. Absalon, Kevin G. McLure, Michael B. Kastan, Regulation of p53 Translation and Induction after DNA Damage by Ribosomal Protein L26 and Nucleolin Cell. ,vol. 123, pp. 49- 63 ,(2005) , 10.1016/J.CELL.2005.07.034
V Ramakrishnan, P.B Moore, Atomic structures at last: the ribosome in 2000. Current Opinion in Structural Biology. ,vol. 11, pp. 144- 154 ,(2001) , 10.1016/S0959-440X(00)00184-6
Lorne J Hofseth, S.Perwez Hussain, Curtis C Harris, p53: 25 years after its discovery. Trends in Pharmacological Sciences. ,vol. 25, pp. 177- 181 ,(2004) , 10.1016/J.TIPS.2004.02.009
Shigeru Kanaoka, Ken-Ichi Yoshida, Naoyuki Miura, Haruhiko Sugimura, Masayoshi Kajimura, Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening Gastroenterology. ,vol. 127, pp. 422- 427 ,(2004) , 10.1053/J.GASTRO.2004.05.022