Personalized medicine: Striding from genes to medicines

摘要: Personalized medicine has the potential of revolutionizing patient care. This treatment modality prescribes therapies specific to individual patients based on pharmacogenetic and pharmacogenomic information. The mapping human genome been an important milestone in understanding interindividual differences response therapy. These are attributed genotypic differences, with consequent phenotypic expression. It is note that targeted should ideally be accompanied by a diagnostic marker. However, most efforts being directed toward developing both these separately; former pharmaceutical companies later companies. Further, this companion strategy will successful only when biomarkers assayed differentiated value-based approach rather than cost-based approach, especially countries reimburse disease management costs. advantages using personalized manifold: population; avoidance drug-related toxicities optimization costs nonresponder patients; reduction drug development costs, fewer tested clinical trials. success therapy future depend better pharmacogenomics extension scientific advances all countries.