Different oxidative stress marker levels in blood from the operated knee or the antecubital vein in patients undergoing knee surgery: a tourniquet-induced ischemia-reperfusion model.
作者： José García-de-la-Asunción , Amparo Perez-Solaz , Miguel Carrau , Francisco Javier Belda , Jaime Perez-Griera
DOI: 10.1179/1351000212Y.0000000022
关键词:
摘要: Background In knee surgery a tourniquet is usually applied in order to provide bloodless surgical field. This study aims compare, tourniquet-induced ischemia–reperfusion model, the glutathione oxidation and lipid peroxidation two different blood sources: an operated drainage tube or antecubital vein. Methods Thirty-two patients undergoing total replacement were studied. We measured reduced (GSH), oxidized (GSSG), malondialdehyde (MDA) other metabolic parameters from (17 patients), vein (15 patients) before inflation (T0) after release at times: 3, 10, 60 minutes (T1, T2, T3, respectively). Results have found early increase of approximately 100% GSSG MDA levels coinciding with decrease GSH T1–T3 knee. These changes also observed T1 but lower ...
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