The mechanism of action of vagus nerve stimulation for refractory epilepsy: the current status.

摘要: Vagus nerve stimulation (VNS) is a neurophysiologic treatment for patients with medically or surgically refractory epilepsy. Since the first human implant in 1989, more than 10,000 have been treated VNS. The precise mechanism of action remains to be elucidated. Animal experiments VNS were initially performed demonstrate efficacy and safety preceding clinical trials patients. Mechanism research involving animal can provide essential clues. are often labor-intensive even hands experienced researchers, however, results remain only reflection complicated pathophysiologic systems brain. particularly challenging because concerns, large number required, heterogenous nature various small patient series. This study provides an overview progress that has made past 10 years through neurophysiologic, neuroanatomic, neurochemical, cerebral blood flow studies animals Further elucidation may increase its efficacy. It also inspiration development new therapeutic modalities