An immunohistochemical and clinicopathological study of gastrointestinal stromal tumors.
作者： Hiroyasu Makuuchi , Yutaka Tsutsumi , Kenichi Tazawa , Kazuhiro Tsukada
DOI: 10.1046/J.1440-1827.1999.00947.X
关键词:
摘要: Immunohistochemical and clinicopathological features of 58 gastrointestinal stromal tumors (GIST) were studied. One occurred in the esophagus, 41 stomach, nine small intestine, seven large intestine. By using indirect immunoperoxidase staining for Cajal cell markers (c-kit protein CD34), smooth muscle (alpha-smooth actin, desmin, heavy caldesmon calponin) Schwann (S-100 Leu 7), GIST classified into five groups, such as type (n = 9), myogenic 5), 2), mixed 40) undifferentiated 2). c-kit Protein (42/58; 72%) CD34 (45/58; 78%) commonly diffusely expressed GIST. Novel markers, (29/58; 50%) calponin (18/58; 31%), useful detecting characters S-100 was 16 (28%) tumors, two which also reactive with 7 (CD57). Three bowel skeinoid fibers categorizable Clinicopathological analyses aggressive 21) non-aggressive indicated that malignant potential correlated intestinal location, tumor size, high cellularity, necrosis, solid (non-interlacing bundled) pattern growth, negativity and/or CD34, mitotic count, MIB-1 labeling.
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