Gastrointestinal autonomic nerve tumors: immunohistochemical and ultrastructural studies in cases of gastrointestinal stromal tumor.

摘要: The gastrolntestlnal autonomic nerve tumor (GAN tumor) is an uncommon stromal with a morphological feature resembling the cell processes of enteric plexus, and was originally teimed plexoma or plexosarcoma. Light microscoplc studies show GAN most often consists spindle-shaped cells indistinguishable from smooth muscle Schwann tumor. Immunohistochemical ultrastructural examinations 18 cases gastrointestinal (GIST) were performed. During examination, all 12 which immunohisto-chemically positive for S-100 protein neuron-specific eno-lase (NSE) showed synapse-like structures containing dense core neurosecretory granules measuring 100–200 nm, 40–60 nm endocytoplasmic vesicles. These results suggest that GIST neurogenlc origln are tumors derived myenteric plexus.