Effects of miso and NaCl on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats
作者： Yoshiyuki Masaoka , Hiromitsu Watanabe , Osamu Katoh , Akihiro Ito , Kiyohiko Dohi
DOI: 10.1080/01635589809514712
关键词:
摘要: The present study was designed to investigate the effects of dietary miso and NaCl supplementation on development aberrant crypt foci (ACF) induced by azoxymethane (AOM) in male F344 rats. A total 76 rats, six weeks age, were divided into seven groups given weekly subcutaneous injections AOM (15 mg/kg body wt) for three induce ACF. animals placed diets one week before first dosing. Group 1 fed a normal diet as control. Groups 2-4 containing 5%, 10%, 20% miso, respectively, 5 6 2.2% 4.4% NaCl, five weeks. 7 without carcinogen exposure. Dietary inhibited ACF dose-dependent manner (y = -3.9x + 140, r -0.94). Thus mean numbers per colon significantly lower 3 4 than (p < 0.01), there fewer crypts 1. associated with ACF, but this not statistically significant. 5-Bromo-2'-deoxyuridine labeling indexes colonic epithelium 0.05). results indicate that could act chemopreventive agent carcinogenesis.
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