Atherosclerotic renal artery stenosis is associated with elevated cell cycle arrest markers related to reduced renal blood flow and postcontrast hypoxia.

摘要: BACKGROUND Atherosclerotic renal artery stenosis (ARAS) reduces blood flow (RBF), ultimately leading to kidney hypoxia and inflammation. Insulin-like growth factor binding protein-7 (IGFBP-7) tissue inhibitor of metalloproteinases-2 (TIMP-2) are biomarkers cell cycle arrest, often increased in ischemic conditions predictive acute injury (AKI). This study sought examine the relationships between vein levels IGFBP-7, TIMP-2, reductions RBF postcontrast as measured by oxygen level-dependent (BOLD) magnetic resonance imaging. METHODS Renal IGFBP-7 TIMP-2 were obtained an ARAS cohort (n= 29) scheduled for stenting essential hypertensive (EH) healthy controls (n = 32). Cortical medullary RBFs multidetector computed tomography (CT) immediately before 3 months later. BOLD imaging was performed after all patients, a subgroup (N 12) underwent repeat 24 h CT/stenting postcontrast/procedure hypoxia. RESULTS Preintervention elevated compared with EH (18.5 ± 2.0 versus 15.7 1.5 97.4 23.1 62.7 9.2 ng/mL, respectively; P< 0.0001); baseline correlated inversely developing contrast injection (r -0.73, 0.0001) prestent cortical -0.59, P= 0.004). CONCLUSION These data demonstrate function degree reduced RBF. Elevated associated protection against postimaging hypoxia, consistent 'ischemic preconditioning'. Despite stenting, AKI these high-risk subjects IGFBP-7/TIMP-2 rare did not affect long-term function.