Analysis of sex-hormone-receptor expression in laryngeal carcinoma

摘要: There are significant differences in how laryngeal cancer affects the two genders, with cases occuring predominantly males. This has been speculated to result from different susceptibilities of tumor cells steroid sex hormones. Since hormone action is mediated by specific cellular receptors, several previous studies have analyzed presence these sex-hormone receptors. However, data on receptor status for androgen, estrogen and progesterone receptors carcinomas controversial. some authors suggested antiandrogen or antiestrogen therapy as an adjuvant treatment carcinoma, we performed a comprehensive study using immunomorphological biochemical techniques both in-vivo in-vitro order clarify whether major present not. We immunohistochemical analysis 13 patients carcinomas, 8 males 5 females, monoclonal antibodies against In addition, was tested biochemically enzyme immune assay (EIA). Furthermore, immunohistochemically expression five keratinocyte cell lines originating carcinomas. all our samples, well tested, did not detect any staining carcinoma when compared positive controls breast prostate samples. Similarly, demonstrate amount protein cases. conclusion, absence male female strongly argues being sex-hormone-dependent tumors. Therefore, do see rational indication use