Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.
作者： Guido Reifenberger , Marietta Wolter , Julia Reifenberger , Markus J. Riemenschneider , Uwe Schlegel
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摘要: We have previously reported on the amplification and overexpression of MDM2 proto-oncogene in a subset malignant gliomas without TP53 mutation (G. Reifenberger et al. , Cancer Res., 53: 2736–2739, 1993). Here, we show that MDM4 ( MDMX ) gene located 1q32 is further target for gliomas. codes Mdm2-related protein can bind to p53 inhibits p53-mediated transcriptional transactivation. investigated series 208 (106 glioblastomas, 46 anaplastic gliomas, 56 low-grade gliomas) identified 5 tumors (4 glioblastomas 1 oligodendroglioma) with overexpression. Several other genes from were found be coamplified such as GAC1 five tumors, REN four RBBP5 three tumors. Additional analyses revealed carried neither mutations conserved regions nor gene. Taken together, our data indicate novel molecular mechanism by which small fraction human escapes p53-dependent growth control.
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genomed-dna.com参考文章(34)
Zanke B, Suzuki H, Squire J, Mak Tw, Henry M, Griesser H, Patterson B, Minden M, A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1. Leukemia. ,vol. 8, pp. 236- 244 ,(1994)
Joseph T. Woitach, Minghuang Zhang, Chien-Hua Niu, Snorri S. Thorgeirsson, A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability Nature Genetics. ,vol. 19, pp. 371- 374 ,(1998) , 10.1038/1258
Andreas von Deimling, Jimmy T. Efird, John W. Henson, David N. Louis, Yasuhiro Ono, Keisuke Ueki, CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated Cancer Research. ,vol. 56, pp. 150- 153 ,(1996)
A. Shvarts, W. T. Steegenga, N. Riteco, T. van Laar, P. Dekker, M. Bazuine, R. C. van Ham, W. van der Houven van Oordt, G. Hateboer, A. J. van der Eb, A. G. Jochemsen, MDMX: a novel p53-binding protein with some functional properties of MDM2. The EMBO Journal. ,vol. 15, pp. 5349- 5357 ,(1996) , 10.1002/J.1460-2075.1996.TB00919.X
Verne M. Chapman, William A. Held, Joseph F. Costello, Joseph F. Costello, Mitchel S. Berger, H. J. Su Huang, Webster K. Cavenee, Christoph Plass, Wadih Arap, Wadih Arap, Cyclin-dependent Kinase 6 (CDK6) Amplification in Human Gliomas Identified Using Two-dimensional Separation of Genomic DNA Cancer Research. ,vol. 57, pp. 1250- 1254 ,(1997)
Thomas Ried, Stanislas du Manoir, Thomas Cremer, Evelin Schròck, Regine Witkowski, Helen Donis-Keller, Peter Nürnberg, Gundula Thiel, Marie-Christine Meffert, Tanka Lozanova, Werner Janisch, Anna Jauch, Michael R Speicher, Siegfried Vogel, Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses. American Journal of Pathology. ,vol. 144, pp. 1203- 1218 ,(1994)
W Wechsler, L Liu, L Liu, G Reifenberger, G Reifenberger, J Reifenberger, C D James, V P Collins, V P Collins, Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. American Journal of Pathology. ,vol. 145, pp. 1175- 1190 ,(1994)
M. Tarkkanen, A.-M. Björkqvist, S. Knuutila, V. Vidgren, O. Monni, W. El-Rifai, K. Autio, M. L. Larramendy, M. Wolf, Ying Zhu, S. Hemmer, J. Szymanska, H. Pere, V.-M. Wasenius, J. Tapper, DNA copy number amplifications in human neoplasms : Review of comparative genomic hybridization studies American Journal of Pathology. ,vol. 152, pp. 1107- 1123 ,(1998)
Masafumi Saijo, Yoshihisa Sakai, Tatsuya Kishino, Norio Niikawa, Yoshiharu Matsuura, Kazuhiko Morino, Katsuyuki Tamai, Yoichi Taya, Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping. Genomics. ,vol. 27, pp. 511- 519 ,(1995) , 10.1006/GENO.1995.1084
Ravikumar Rallapalli, Gordon Strachan, Brian Cho, W. Edward Mercer, David J. Hall, A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity. Journal of Biological Chemistry. ,vol. 274, pp. 8299- 8308 ,(1999) , 10.1074/JBC.274.12.8299