C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
作者： Michael O. Hengartner , H.Robert Horvitz
DOI: 10.1016/0092-8674(94)90506-1
关键词:
摘要: The activity of the C. elegans gene ced-9 is required to protect cells that normally survive from undergoing programmed cell death. Here we describe cloning and molecular characterization this gene. an element a polycistronic locus also contains cyt-1, which encodes protein similar cytochrome b560 complex II mitochondrial respiratory chain. 280 amino acid showing sequence structural similarities mammalian proto-oncogene bcl-2. Overexpression bcl-2 can mimic protective effect on death prevent ectopic deaths occur in loss-of-function mutants. These results suggest are homologs mechanism has been conserved nematodes mammals.
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