Mutation analysis of P73 and TP53 in Merkel cell carcinoma.

摘要: The p73 gene has been mapped to 1p36.33, a region which is frequently deleted in wide variety of neoplasms including tumours neuroectodermal origin. protein shows structural and functional homology p53. For these reasons, was considered as positional candidate tumour suppressor gene. Thus far, mutation analysis provided no evidence for involvement oligodendrogliomas, lung carcinoma, oesophageal prostatic carcinoma hepatocellular carcinoma. In neuroblastoma, two mutations have observed series 140 tumours. view the occurrence 1p deletions Merkel cell (MCC) location we decided search five MCC lines ten test potential function this MCC. possible complementary functions TP53 also examined status Sequence entire coding revealed previously reported polymorphisms four MCCs. one tumour, mis-sense located NH2-terminal transactivation found. These results show that p73, analogous infrequently mutated This first report role investigated by sequencing TP53. non-sense were detected three 15 MCCs, suggesting may play pathogenesis or progression subset Moreover, typical UVB induced C T found line thus providing further sun-exposure aetiology rare skin cancer. © 2000 Cancer Research Campaign