Influence of structure on release profile of acyclovir loaded polyurethane nanofibers: Monolithic and core/shell structures
作者： Maryam Azizi , Mir Saeed Seyed Dorraji , Mohammad Hossein Rasoulifard
DOI: 10.1002/APP.44073
关键词:
摘要: In this study, monolithic and core/shell polyurethane (PU) nanofibers were fabricated by single coaxial electrospinning techniques, respectively. An antivirus drug, Acyclovir (ACY), was loaded on PU nanofibers. The physical condition interaction of the ACY within these studied FTIR, XRD, DSC, SEM, TEM. vitro tests exhibited an obvious difference in release pattern between burst could be controlled structure. Release profile found to follow Korsmeyere-Peppas model with Fickian diffusion mechanism. Our study demonstrated that ACY-loaded might serve as a device for drug delivery systems. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44073.
sci-hub.se 参考文章(28)
Padala Narasimha Murthy, Prasanta Chowdhury, Lilakanta Nath, Suvakanta Dash, Kinetic modeling on drug release from controlled drug delivery systems Acta Poloniae Pharmaceutica. ,vol. 67, pp. 217- 223 ,(2010)
Yong-Hui Wu, Deng-Guang Yu, Xiao-Yan Li, Ai-Hua Diao, Upulitha Eranka Illangakoon, Gareth R. Williams, Fast-dissolving sweet sedative nanofiber membranes Journal of Materials Science. ,vol. 50, pp. 3604- 3613 ,(2015) , 10.1007/S10853-015-8921-4
Jie Yan, Kenneth White, Deng-Guang Yu, Xu-Yao Zhao, Sustained-release multiple-component cellulose acetate nanofibers fabricated using a modified coaxial electrospinning process Journal of Materials Science. ,vol. 49, pp. 538- 547 ,(2014) , 10.1007/S10853-013-7733-7
Baljit Singh, R. Bala, Design of dietary polysaccharide and binary monomer mixture of acrylamide and 2-acrylamido-2-methylpropane sulphonic acid based antiviral drug delivery devices Chemical Engineering Research & Design. ,vol. 90, pp. 346- 358 ,(2012) , 10.1016/J.CHERD.2011.07.023
Vince Beachley, Xuejun Wen, Effect of electrospinning parameters on the nanofiber diameter and length Materials Science and Engineering: C. ,vol. 29, pp. 663- 668 ,(2009) , 10.1016/J.MSEC.2008.10.037
Hualin Wang, Yi She, Chengjiang Chu, Huan Liu, Suwei Jiang, Min Sun, Shaotong Jiang, Preparation, antimicrobial and release behaviors of nisin-poly (vinyl alcohol)/wheat gluten/ZrO2 nanofibrous membranes Journal of Materials Science. ,vol. 50, pp. 5068- 5078 ,(2015) , 10.1007/S10853-015-9059-0
Sheng-Feng Hung, Chien-Ming Hsieh, Ying-Chen Chen, Yu-Chun Wang, Hsiu-O Ho, Ming-Thau Sheu, Characterizations of Plasticized Polymeric Film Coatings for Preparing Multiple-Unit Floating Drug Delivery Systems (muFDDSs) with Controlled-Release Characteristics PLoS ONE. ,vol. 9, pp. e100321- ,(2014) , 10.1371/JOURNAL.PONE.0100321
Andreas Greiner, Joachim H. Wendorff, Electrospinning: A Fascinating Method for the Preparation of Ultrathin Fibers Angewandte Chemie. ,vol. 46, pp. 5670- 5703 ,(2007) , 10.1002/ANIE.200604646
Theresa M Allen, Pieter R Cullis, Drug Delivery Systems: Entering the Mainstream Science. ,vol. 303, pp. 1818- 1822 ,(2004) , 10.1126/SCIENCE.1095833
Chen Yu, Liu Yun-Fei, Tan Hui-Min, Hydroxyethyl chitosan-g-poly(acrylic acid-co-sodium acrylate) superabsorbent polymers Journal of Applied Polymer Science. ,vol. 117, pp. 2233- 2240 ,(2010) , 10.1002/APP.32141