Prognostic role of matrix metalloproteinases in bladder carcinoma: a systematic review and meta-analysis.

摘要: // Chenkui Miao 1,* , Chao Liang Jundong Zhu Aiming Xu 1 Kai Zhao Yibo Hua Jianzhong Zhang Wei Chen 2 Chuanjian Suo Yiyang Liu Shifeng Su and Zengjun Wang State Key Laboratory of Reproductive Medicine Department Urology, The First Affiliated Hospital Nanjing Medical University, Nanjing, People’s Republic China Hospital, * These authors have contributed equally to this work Correspondence to: Wang, email: Su, Keywords : matrix metalloproteinases, bladder cancer, prognosis, meta-analysis Received September 06, 2016 Accepted February 21, 2017 Published March 04, Abstract Recent studies shown that metalloproteinases (MMPs) might be a biomarker for predicting outcomes cancer. However, the prognostic value overexpression MMPs in cancer is debatable are inconsistent. Therefore, was performed clarify specific association carcinoma. Relevant were identified by searching PubMed, EMBASE, Web Science. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) disease-specific survival (DSS), overall (OS), disease/recurrence-free (DFS/RFS), progression/metastasis-free (PFS/MFS) analyzed determine MMPs. In total, eighteen applicable included meta-analysis. We found high expression significantly correlated poor DSS OS (HR=1.66; CI = 1.38–2.01 HR= 1.67; 95%CI= 1.26–2.22). also predicted tumor progression metastasis pooled HR 3.03 (95% 1.98–4.64). had no pivotal impact on DFS/RFS (HR= 1.21; CI= 0.96–1.53). With purpose better understanding role patients wirh carcinoma, we carried out systematic review