Electrical stimulation in the bed nucleus of the stria terminalis alleviates severe obsessive-compulsive disorder.
作者： L Luyten , S Hendrickx , S Raymaekers , L Gabriëls , B Nuttin
DOI: 10.1038/MP.2015.124
关键词:
摘要: In 1998, we proposed deep brain stimulation as a last-resort treatment option for patients suffering from severe, treatment-resistant obsessive-compulsive disorder (OCD). Here, 24 OCD were included in long-term follow-up study to evaluate the effects of electrical anterior limbs internal capsule (ALIC) and bed nucleus stria terminalis (BST). We find that ALIC/BST area is safe significantly decreases obsessions, compulsions, associated anxiety depressive symptoms, improves global functioning blinded crossover trial (n=17), after 4 years (n=18), at last (up 171 months, n=24). Moreover, our data indicate BST may be better target compared with ALIC alleviate symptoms. conclude promising therapeutic otherwise patients.
nature.com
sci-hub.se 参考文章(43)
Mathieu Sprengers, Kristl Vonck, Evelien Carrette, Anthony G Marson, Paul Boon, Deep brain and cortical stimulation for epilepsy Cochrane Database of Systematic Reviews. ,vol. 7, pp. 0- 0 ,(2017) , 10.1002/14651858.CD008497.PUB3
Leah H. Somerville, Paul J. Whalen, William M. Kelley, Human Bed Nucleus of the Stria Terminalis Indexes Hypervigilant Threat Monitoring Biological Psychiatry. ,vol. 68, pp. 416- 424 ,(2010) , 10.1016/J.BIOPSYCH.2010.04.002
Michael Davis, David L Walker, Leigh Miles, Christian Grillon, Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology. ,vol. 35, pp. 105- 135 ,(2010) , 10.1038/NPP.2009.109
David L Walker, Donna J Toufexis, Michael Davis, Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety European Journal of Pharmacology. ,vol. 463, pp. 199- 216 ,(2003) , 10.1016/S0014-2999(03)01282-2
Stephen C. Heinrichs, Neurobehavioral consequences of stressor exposure in rodent models of epilepsy Progress in Neuro-Psychopharmacology and Biological Psychiatry. ,vol. 34, pp. 808- 815 ,(2010) , 10.1016/J.PNPBP.2009.11.002
Laura Luyten, Kris van Kuyck, Debora Vansteenwegen, Bart Nuttin, Electrolytic lesions of the bed nucleus of the stria terminalis disrupt freezing and startle potentiation in a conditioned context. Behavioural Brain Research. ,vol. 222, pp. 357- 362 ,(2011) , 10.1016/J.BBR.2011.03.066
Peter W. Kaplan, Obsessive-compulsive disorder in chronic epilepsy. Epilepsy & Behavior. ,vol. 22, pp. 428- 432 ,(2011) , 10.1016/J.YEBEH.2011.07.029
Jamie Maguire, Jay A. Salpekar, Stress, seizures, and hypothalamic–pituitary–adrenal axis targets for the treatment of epilepsy Epilepsy & Behavior. ,vol. 26, pp. 352- 362 ,(2013) , 10.1016/J.YEBEH.2012.09.040
Michael S. Okun, Dawn Bowers, Utaka Springer, Nathan A. Shapira, Donald Malone, Ali R. Rezai, Bart Nuttin, Kenneth M. Heilman, Robert J. Morecraft, Steven A. Rasmussen, Benjamin D. Greenberg, Kelly D. Foote, Wayne K. Goodman, What's in a “Smile?” Intra-operative Observations of Contralateral Smiles Induced by Deep Brain Stimulation Neurocase. ,vol. 10, pp. 271- 279 ,(2004) , 10.1080/13554790490507632
B D Greenberg, L A Gabriels, D A Malone, A R Rezai, G M Friehs, M S Okun, N A Shapira, K D Foote, P R Cosyns, C S Kubu, P F Malloy, S P Salloway, J E Giftakis, M T Rise, A G Machado, K B Baker, P H Stypulkowski, W K Goodman, S A Rasmussen, B J Nuttin, Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experience. Molecular Psychiatry. ,vol. 15, pp. 64- 79 ,(2010) , 10.1038/MP.2008.55