Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

Ian Tomlinson, Emily Webb, Luis Carvajal-Carmona, Peter Broderick, Zoe Kemp, Sarah Spain, Steven Penegar, Ian Chandler, Maggie Gorman, Wendy Wood, Ella Barclay, Steven Lubbe, Lynn Martin, Gabrielle Sellick, Emma Jaeger, Richard Hubner, Ruth Wild, Andrew Rowan, Sarah Fielding, Kimberley Howarth, CORGI Consortium, Andrew Silver, Wendy Atkin, Kenneth Muir, Richard Logan, David Kerr, Elaine Johnstone, Oliver Sieber, Richard Gray, Huw Thomas, Julian Peto, Jean-Baptiste Cazier, Richard Houlston, None, A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nature Genetics. ,vol. 39, pp. 984- 988 ,(2007) , 10.1038/NG2085

Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, SEARCH collaborators Luccarini Craig 61 Conroy Don 61 Shah Mitul 61 Munday Hannah 61 Jordan Clare 61 Perkins Barbara 61 West Judy 61 Redman Karen 61 Driver Kristy 61, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, Suleeporn Sangrajrang, Valerie Gaborieau, Fabrice Odefrey, Chen-Yang Shen, Pei-Ei Wu, Hui-Chun Wang, Diana Eccles, D Gareth Evans, Julian Peto, Olivia Fletcher, Nichola Johnson, Sheila Seal, Michael R Stratton, Nazneen Rahman, Georgia Chenevix-Trench, Stig E Bojesen, Børge G Nordestgaard, Christen K Axelsson, Montserrat Garcia-Closas, Louise Brinton, Stephen Chanock, Jolanta Lissowska, Beata Peplonska, Heli Nevanlinna, Rainer Fagerholm, Hannaleena Eerola, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, David J Hunter, Susan E Hankinson, David G Cox, Per Hall, Sara Wedren, Jianjun Liu, Yen-Ling Low, Natalia Bogdanova, Peter Schürmann, Thilo Dörk, Rob AEM Tollenaar, Catharina E Jacobi, Peter Devilee, Jan GM Klijn, Alice J Sigurdson, Michele M Doody, Bruce H Alexander, Jinghui Zhang, Angela Cox, Ian W Brock, Gordon MacPherson, Malcolm WR Reed, Fergus J Couch, Ellen L Goode, Janet E Olson, Hanne Meijers-Heijboer, Ans van den Ouweland, André Uitterlinden, Fernando Rivadeneira, Roger L Milne, Gloria Ribas, Anna Gonzalez-Neira, Javier Benitez, John L Hopper, Margaret McCredie, Melissa Southey, Graham G Giles, Chris Schroen, Christina Justenhoven, Hiltrud Brauch, Ute Hamann, Yon-Dschun Ko, Amanda B Spurdle, Jonathan Beesley, Xiaoqing Chen, AOCS Management Group Bowtell David 146 Green Adele 82 deFazio Anna 147 Chenevix-Trench Georgia 82 Gertig Dorota 111 Webb Penny 82, Arto Mannermaa, Veli-Matti Kosma, Vesa Kataja, Jaana Hartikainen, Nicholas E Day, David R Cox, Bruce AJ Ponder, None, Genome-wide association study identifies novel breast cancer susceptibility loci Nature. ,vol. 447, pp. 1087- 1093 ,(2007) , 10.1038/NATURE05887

SC Whitelaw, VA Murday, IP Tomlinson, HJ Thomas, S Cottrell, A Ginsberg, S Bukofzer, SV Hodgson, RB Skudowitz, JR Jass, IC Talbot, JM Northover, WF Bodmer, E Solomon, Clinical and molecular features of the hereditary mixed polyposis syndrome. Gastroenterology. ,vol. 112, pp. 327- 334 ,(1997) , 10.1053/GAST.1997.V112.PM9024286

Fred S. Guthery, Kenneth P. Burnham, David R. Anderson, Model Selection and Multimodel Inference: A Practical Information-Theoretic Approach The Journal of Wildlife Management. ,vol. 67, pp. 655- ,(2003) , 10.2307/3802723

Tong Sun, Yang Gao, Wen Tan, Sufang Ma, Yuankai Shi, Jiarui Yao, Yongli Guo, Ming Yang, Xuemei Zhang, Qingrun Zhang, Changqing Zeng, Dongxin Lin, A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. Nature Genetics. ,vol. 39, pp. 605- 613 ,(2007) , 10.1038/NG2030

Christopher A Haiman, Nick Patterson, Matthew L Freedman, Simon R Myers, Malcolm C Pike, Alicja Waliszewska, Julie Neubauer, Arti Tandon, Christine Schirmer, Gavin J McDonald, Steven C Greenway, Daniel O Stram, Loic Le Marchand, Laurence N Kolonel, Melissa Frasco, David Wong, Loreall C Pooler, Kristin Ardlie, Ingrid Oakley-Girvan, Alice S Whittemore, Kathleen A Cooney, Esther M John, Sue A Ingles, David Altshuler, Brian E Henderson, David Reich, Multiple regions within 8q24 independently affect risk for prostate cancer. Nature Genetics. ,vol. 39, pp. 638- 644 ,(2007) , 10.1038/NG2015

Nabil G Seidah, Michel Chrétien, Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Research. ,vol. 848, pp. 45- 62 ,(1999) , 10.1016/S0006-8993(99)01909-5

Julius Gudmundsson, Patrick Sulem, Andrei Manolescu, Laufey T Amundadottir, Daniel Gudbjartsson, Agnar Helgason, Thorunn Rafnar, Jon T Bergthorsson, Bjarni A Agnarsson, Adam Baker, Asgeir Sigurdsson, Kristrun R Benediktsdottir, Margret Jakobsdottir, Jianfeng Xu, Thorarinn Blondal, Jelena Kostic, Jielin Sun, Shyamali Ghosh, Simon N Stacey, Magali Mouy, Jona Saemundsdottir, Valgerdur M Backman, Kristleifur Kristjansson, Alejandro Tres, Alan W Partin, Marjo T Albers-Akkers, Javier Godino-Ivan Marcos, Patrick C Walsh, Dorine W Swinkels, Sebastian Navarrete, Sarah D Isaacs, Katja K Aben, Theresa Graif, John Cashy, Manuel Ruiz-Echarri, Kathleen E Wiley, Brian K Suarez, J Alfred Witjes, Mike Frigge, Carole Ober, Eirikur Jonsson, Gudmundur V Einarsson, Jose I Mayordomo, Lambertus A Kiemeney, William B Isaacs, William J Catalona, Rosa B Barkardottir, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong, Kari Stefansson, Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nature Genetics. ,vol. 39, pp. 631- 637 ,(2007) , 10.1038/NG1999

Ian Tomlinson, Nazneen Rahman, Ian Frayling, Jon Mangion, Rita Barfoot, Rifat Hamoudi, Sheila Seal, John Northover, Huw J.W. Thomas, Kay Neale, Shirley Hodgson, Ian Talbot, Richard Houlston, Michael R. Stratton, Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22. Gastroenterology. ,vol. 116, pp. 789- 795 ,(1999) , 10.1016/S0016-5085(99)70061-2

J. B. Sneddon, H. H. Zhen, K. Montgomery, M. van de Rijn, A. D. Tward, R. West, H. Gladstone, H. Y. Chang, G. S. Morganroth, A. E. Oro, P. O. Brown, Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 14842- 14847 ,(2006) , 10.1073/PNAS.0606857103