Should we keep rocking? Portraits from targeting Rho kinases in cancer.

摘要: Cancer targeted therapy, either alone or in combination with conventional chemotherapy, could allow the survival of patients neoplasms currently considered incurable. In recent years, dysregulation Rho-associated coiled-coil kinases (ROCK1 and ROCK2) has been associated increased metastasis poorer patient several tumor types, due to their essential roles regulating cytoskeleton, have gained popularity progressively researched as targets for development novel anti-cancer drugs. Nevertheless, a pediatric scenario, influence both isoforms on prognosis remains controversial issue. this review, we summarize functions ROCKs, compile human cancer value prognostic factors both, adult cancer. Moreover, provide up-to-date advances pharmacological inhibition pre-clinical models clinical trials. Alternatively, highlight discuss detrimental effects ROCK provoked not only by action off-targets, but most importantly, pro-survival stem cells, dormant circulating along cell-context microenvironment-dependent contradictory responses. Together these drawbacks represent risk cell dissemination after anti-ROCK intervention, caveat that should concern scientists clinicians.