Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging.

摘要: Objectives This study sought to evaluate whether pulse wave velocity (PWV), a noninvasive index of arterial stiffness, is predictor the longitudinal changes in systolic blood pressure (SBP) and incident hypertension. Background Although stiffness believed underlie, part, age-associated SBP, particularly at older ages, few studies humans have examined relationship between pressure. Methods Pulse was measured baseline 449 normotensive or untreated hypertensive volunteers (age 53 ± 17 years). Repeated measurements were performed during an average follow-up 4.9 2.5 years. Results After adjusting for covariates including age, body mass index, mean pressure, linear mixed effects regression models showed that PWV independent determinant increase SBP (p = 0.003 interaction term with time). In subset 306 subjects who baseline, hypertension developed 105 (34%) median 4.3 years (range 2 12 By stepwise Cox proportional hazards models, (hazard ratio 1.10 per 1 m/s PWV, 95% confidence interval 1.00 1.30, p 0.03) individuals duration greater than median. Conclusions suggests could help identify should be targeted implementation interventions aimed preventing delaying progression subclinical stiffening onset