Susceptibility gradient mapping (SGM): A new postprocessing method for positive contrast generation applied to superparamagnetic iron oxide particle (SPIO)-labeled cells

摘要: Local susceptibility gradients result in a dephasing of the precessing magnetic moments and thus fast decay NMR signals. In particular, cells labeled with superparamagnetic iron oxide particles (SPIOs) induce hypointensities, making vivo detection from such negative image contrast difficult. this work, new method is proposed to selectively turn into positive contrast. The calculates gradient visualizes it parametric map directly regular gradient-echo dataset. determined postprocessing step, requiring no dedicated pulse sequences or adaptation sequence before during acquisition. Phantom experiments demonstrated that local differences can be quantified. showed feasibility for tracking SPIO-labeled cells. bears potential also usage other applications, including agents interventional devices as well metal implants.