Neurochemical mechanisms induced by high frequency stimulation of the subthalamic nucleus: increase of extracellular striatal glutamate and GABA in normal and hemiparkinsonian rats.

摘要: High frequency stimulation (HFS) (130 Hz) of the subthalamic nucleus (STN) provides beneficial effects in patients suffering from severe parkinsonism, but mechanisms underlying these clinical results remain to be clarified. To date, very little is known concerning STN-HFS on neurochemical transmission different basal ganglia nuclei and particular striatum. This study examines intact hemiparkinsonian rats extracellular striatal glutamate (Glu) GABA levels by means intracerebral microdialysis. Unilateral was found induce a significant bilateral increase Glu both dopamine-lesioned animals. In rats, increases were reversed local administration D1 antagonist SCH 23390, potentiated D2 sulpiride. Potentiation also observed after antagonists whose amplitude similar that measured rats. These data furnish first evidence influences amino-acid this influence modulated dopamine. They provide are not only restricted direct STN targets, involve adaptive changes within other structures circuitry.