Immune heterogeneity and clinicopathologic characterization of IGFBP2 in 2447 glioma samples.
作者： Jinquan Cai , Qun Chen , Yuqiong Cui , Jiawei Dong , Meng Chen
DOI: 10.1080/2162402X.2018.1426516
关键词:
摘要: ABSTRACTGlioblastoma is an immunosuppressive, deadly brain tumor. IGFBP2, a circulating biomarker for cancer diagnosis and potential immunotherapeutic target, attracting more attention from oncologists clinicians. Thus, it urgent to thoroughly investigate the immune biological process of IGFBP2 understand tumor complexity provide evidence anti-IGFBP2 therapy. Through authoritative public databases, we enrolled total 2447 glioma samples with gene expression profiles. Then, clinical characteristics immunosuppressive status in were analyzed. Immunohistochemical staining detected biomarkers. We found that was upregulated high-grade GBM downregulated IDH mutant glioma. Increased accompanied PTEN loss EGFR amplification. Bioinformatic analysis revealed related immunological processes. further selected specific immuno...
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