ESR1 Gene Variants Are Predictive of Osteoporosis in Female Patients with Crohn's Disease.
作者： Iwona Krela-Kaźmierczak , Marzena Skrzypczak-Zielińska , Marta Kaczmarek-Ryś , Michał Michalak , Aleksandra Szymczak-Tomczak
DOI: 10.3390/JCM8091306
关键词:
摘要: Decreased bone mass in patients with inflammatory bowel diseases (IBD) is a clinical problem extremely severe consequences of osteoporotic fractures. Despite its increasing prevalence and the need for mandatory intervention monitoring, it often ignored IBD patients’ care. Determining biomarkers susceptibility to mineral density disorder appears be indispensable. We aim investigate impact estrogen receptor gene (ESR1) polymorphisms on (BMD) ulcerative colitis (UC) Crohn’s disease (CD), as they may contribute both, osteoporosis processes. characterised 197 (97 UC, 100 CD), 41 controls carrying out vitamin D, calcium phosphorus serum levels, assessment at lumbar spine femoral neck by dual-energy X-ray absorptiometry (DXA), ESR1 genotyping haplotype analysis. observed that women CD showed lowest parameters, which corresponded c.454-397T c.454-351A allele dose. The PvuII XbaI TA (px) correlated decreased T-score (OR = 2.75, CI [1.21–6.27], P-value 0.016) predictive female CD.
mdpi.com
sci-hub.se 参考文章(52)
Janka Bábíčková, Ľubomíra Tóthová, Eva Lengyelová, Anastázie Bartoňová, Július Hodosy, Roman Gardlík, Peter Celec, Sex Differences in Experimentally Induced Colitis in Mice: a Role for Estrogens. Inflammation. ,vol. 38, pp. 1996- 2006 ,(2015) , 10.1007/S10753-015-0180-7
Yasser EZZAT, Khaled HAMDY, The frequency of low bone mineral density and its associated risk factors in patients with inflammatory bowel diseases International Journal of Rheumatic Diseases. ,vol. 13, pp. 259- 265 ,(2010) , 10.1111/J.1756-185X.2010.01542.X
Lorena Rodríguez-Bores, Josué Barahona-Garrido, Jesús K Yamamoto-Furusho, Basic and clinical aspects of osteoporosis in inflammatory bowel disease World Journal of Gastroenterology. ,vol. 13, pp. 6156- 6165 ,(2007) , 10.3748/WJG.V13.I46.6156
Li Tang, Guo-Lin Cheng, Zhong-Hua Xu, None, Association between estrogen receptor α gene (ESR1) PvuII (C/T) and XbaI (A/G) polymorphisms and hip fracture risk: evidence from a meta-analysis. PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0082806
Attila Molvarec, Gábor Széplaki, Margit Kovács, Zoltán Széplaki, Ádám Fazakas, Zoltán Prohászka, George Füst, István Karádi, Estrogen receptor α (ESR1) PvuII and XbaI gene polymorphisms in ischemic stroke in a Hungarian population Clinica Chimica Acta. ,vol. 382, pp. 100- 105 ,(2007) , 10.1016/J.CCA.2007.04.003
Juan Pablo Méndez, David Rojano-Mejía, Ramón Mauricio Coral-Vázquez, Agustín Coronel, Javier Pedraza, María José Casas, Ruth Soriano, Eduardo García-García, Felipe Vilchis, Patricia Canto, Impact of genetic variants of IL-6, IL6R, LRP5, ESR1 and SP7 genes on bone mineral density in postmenopausal Mexican-Mestizo women with obesity. Gene. ,vol. 528, pp. 216- 220 ,(2013) , 10.1016/J.GENE.2013.07.008
Hayley D. McKeen, Christopher Byrne, Puthen V. Jithesh, Christopher Donley, Andrea Valentine, Anita Yakkundi, Martin O'Rourke, Charles Swanton, Helen O. McCarthy, David G. Hirst, Tracy Robson, FKBPL Regulates Estrogen Receptor Signaling and Determines Response to Endocrine Therapy Cancer Research. ,vol. 70, pp. 1090- 1100 ,(2009) , 10.1158/0008-5472.CAN-09-2515
J. R. Long, Y. Y. Zhang, P. Y. Liu, Y. J. Liu, H. Shen, V. Dvornyk, L. J. Zhao, H. W. Deng, Association of Estrogen Receptor α and Vitamin D Receptor Gene Polymorphisms with Bone Mineral Density in Chinese Males Calcified Tissue International. ,vol. 74, pp. 270- 276 ,(2004) , 10.1007/S00223-003-0087-4
MaryFran Sowers, Mary L. Jannausch, Wei Liang, Marcia Willing, Estrogen receptor genotypes and their association with the 10-year changes in bone mineral density and osteocalcin concentrations. The Journal of Clinical Endocrinology and Metabolism. ,vol. 89, pp. 733- 739 ,(2004) , 10.1210/JC.2003-030691
Natalie A. Molodecky, Ing Shian Soon, Doreen M. Rabi, William A. Ghali, Mollie Ferris, Greg Chernoff, Eric I. Benchimol, Remo Panaccione, Subrata Ghosh, Herman W. Barkema, Gilaad G. Kaplan, Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review Gastroenterology. ,vol. 142, pp. 46- 54 ,(2012) , 10.1053/J.GASTRO.2011.10.001