Multiple chromosomal abnormalities in human liver (pre)neoplasia.
作者： Maria Raidl , Christine Pirker , Rolf Schulte-Hermann , Michaela Aubele , Daniela Kandioler-Eckersberger
DOI: 10.1016/J.JHEP.2003.12.020
关键词: DNA 、 Hepatocellular carcinoma 、 HCCS 、 Chromosome 、 Pathology 、 Hepatocellular adenoma 、 Focal nodular hyperplasia 、 Biology 、 Lung 、 Nodule (medicine)
摘要: Abstract Background/Aims In human hepatocarcinogenesis the tumor precursor lesions and sequence of genetic aberrations are not known. We therefore compared alterations different types benign liver to those hepatocellular carcinoma. Methods By comparative genomic hybridisation (CGH) 40 cases, including cirrhotic (CL), focal nodular hyperplasia (FNHs), adenoma (HCAs), dysplastic nodules (DNs), primary carcinoma (HCCs), metastases lung were studied. Results FNHs HCAs exhibited few chromosomal abnormalities. Frequency pattern in DNs highly resembled HCCs: gains DNA clustered chromosome arms 1p/q, 7q, 15q, 16p, 17q, 20q losses often found at 3p, 4q, 9p, 11q. Aberrations on 1p, 6q, 8p/q, 13q occurred almost exclusively HCCs; gain 8q encompassed amplification c-myc, as verified by fluorescence situ hybridisation. Conclusions The HCCs more than HCAs, suggesting that may be actual precursors. Furthermore, 11q, 17q appear early events being crucial for hepatocarcinogenesis.
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sci-hub.se 参考文章(55)
Joe W. Grisham, Molecular Genetic Alterations in Primary Hepatocellular Neoplasms Humana Press, Totowa, NJ. pp. 269- 346 ,(2002) , 10.1007/978-1-59259-125-1_14
Masahiro Arakawa, Masayoshi Kage, Shigetaka Sugihara, Toshiro Nakashima, Masahiro Suenaga, Kunio Okuda, Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver Gastroenterology. ,vol. 91, pp. 198- 208 ,(1986) , 10.1016/0016-5085(86)90458-0
The molecular basis of human cancer Humana Press. ,(2002) , 10.1007/978-1-59259-125-1
Kunio Okuda, Kunio Okuda, Kunio Okuda, Masahiro Suenaga, Masahiro Suenaga, Masahiro Suenaga, Masahiro Arakawa, Masahiro Arakawa, Masahiro Arakawa, Shigetaka Sugihara, Shigetaka Sugihara, Shigetaka Sugihara, Masayoshi Kage, Masayoshi Kage, Masayoshi Kage, Toshiro Nakashima, Toshiro Nakashima, Toshiro Nakashima, Emergence of Malignant Lesions Within an Adenomatous Hyperplastic Nodule in a Cirrhotic Liver Gastroenterology. ,vol. 91, pp. 198- 208 ,(1986) , 10.5555/URI:PII:0016508586904580
Hugh A. Edmondson, Paul E. Steiner, Primary carcinoma of the liver.A study of 100 cases among 48,900 necropsies Cancer. ,vol. 7, pp. 462- 503 ,(1954) , 10.1002/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E
Christine Pirker, Klaus Holzmann, Sabine Spiegl-Kreinecker, Leonilla Elbling, Christiane Thallinger, Hubert Pehamberger, Michael Micksche, Walter Berger, Chromosomal imbalances in primary and metastatic melanomas: over-representation of essential telomerase genes. Melanoma Research. ,vol. 13, pp. 483- 492 ,(2003) , 10.1097/00008390-200310000-00007
A Kallioniemi, O. Kallioniemi, D Sudar, D Rutovitz, J. Gray, F Waldman, D Pinkel, Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors Science. ,vol. 258, pp. 818- 821 ,(1992) , 10.1126/SCIENCE.1359641
Ruthild G. Weber, Martin Scheer, I. Antonio Born, Stefan Joos, J. M. J. Ludwig Cobbers, Christof Hofele, Guido Reifenberger, Joachim E. Zöller, Peter Lichter, Recurrent Chromosomal Imbalances Detected in Biopsy Material from Oral Premalignant and Malignant Lesions by Combined Tissue Microdissection, Universal DNA Amplification, and Comparative Genomic Hybridization The American Journal of Pathology. ,vol. 153, pp. 295- 303 ,(1998) , 10.1016/S0002-9440(10)65571-X
Keng-Hsin Lan, Meei-Ling Sheu, Shinn-Jang Hwang, Sang-Hue Yen, Shiow-Yi Chen, Jaw-Ching Wu, Yuan-Jan Wang, Naoya Kato, Masao Omata, Full-Young Chang, Shou-Dong Lee, HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis Oncogene. ,vol. 21, pp. 4801- 4811 ,(2002) , 10.1038/SJ.ONC.1205589
Cesar Labarca, Kenneth Paigen, A simple, rapid, and sensitive DNA assay procedure. Analytical Biochemistry. ,vol. 102, pp. 344- 352 ,(1980) , 10.1016/0003-2697(80)90165-7