Retinal Arteriolar Tortuosity is Associated With Retinopathy and Early Kidney Dysfunction in Type 1 Diabetes

摘要: Purpose To examine the association of retinal vessel tortuosity with diabetic retinopathy and early nephropathy in type 1 diabetes. Design Cross-sectional. Methods A total 1159 participants diabetes aged 12 to 20 years, attending clinics Children's Hospital at Westmead, Sydney, Australia between 1990 2002, were included. Retinal photography clinical examinations performed during baseline visit assess albumin excretion rate (AER). was measured from digitized photographs using a semi-automated computer program by single grader masked participants' characteristics. Diabetic defined as ETDRS level ≥21 (mild nonproliferative retinopathy) kidney dysfunction AER ≥7.5 μg/min. Results Of 944 patients (81.4%), 85 (9.0%) had signs only, 250 (26.5%) both dysfunction. In multivariate analysis, higher arteriolar associated (odds ratio [OR] 2.01, 95% confidence interval [CI] 1.23-3.29, highest quartile vs remaining 3 quartiles), (OR 1.56, CI 1.06-2.28, per standard deviation [SD] increase), or coexistence complications 1.96, 1.21-3.24, quartiles). Conclusions Greater independently stage These findings may offer potential quantitative measurement for complication risk assessment.