Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor

作者: Marta Portela , Linda M Parsons , Nicola A Grzeschik , Helena E Richardson

DOI: 10.1080/15384101.2015.1026515

关键词: Hippo signaling pathwayBiologySuppressorEndosomeCell biologyEndocytosisV-ATPaseNotch signaling pathwaySignal transductionEpithelium

摘要: The evolutionarily conserved neoplastic tumor suppressor protein, Lethal (2) giant larvae (Lgl), plays roles in cell polarity and tissue growth via regulation of the Hippo pathway. In our recent study, we showed that developing Drosophila eye epithelium, depletion Lgl leads to increased ligand-dependent Notch signaling. lgl mutant also exhibits an accumulation early endosomes, recycling early-multivesicular body markers acidic vesicles. We elevated signaling lgl− can be rescued by feeding vesicle de-acidifying drug chloroquine, revealing attenuates limiting acidification. Strikingly, chloroquine overgrowth phenotype, suggesting pathway defects were rescued. this extraview, provide additional data on endocytosis Lgl, discuss possible mechanisms which contributes defects...

参考文章(94)
Shinya Yamamoto, Wu-Lin Charng, Hugo J. Bellen, Endocytosis and Intracellular Trafficking of Notch and Its Ligands Current Topics in Developmental Biology. ,vol. 92, pp. 165- 200 ,(2010) , 10.1016/S0070-2153(10)92005-X
Vivek A. Rudrapatna, Ross L. Cagan, Tirtha K. Das, Drosophila cancer models Developmental Dynamics. ,vol. 241, pp. 107- 118 ,(2012) , 10.1002/DVDY.22771
Spyros Artavanis-Tsakonas, Marc A.T. Muskavitch, Notch: The Past, the Present, and the Future Current Topics in Developmental Biology. ,vol. 92, pp. 1- 29 ,(2010) , 10.1016/S0070-2153(10)92001-2
Tomokazu Ohshiro, Takako Yagami, Chuan Zhang, Fumio Matsuzaki, Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature. ,vol. 408, pp. 593- 596 ,(2000) , 10.1038/35046087
Louise Y Cheng, Linda M Parsons, Helena E Richardson, Modelling Cancer in Drosophila: The Next Generation eLS. pp. 1- 17 ,(2013) , 10.1002/9780470015902.A0020862.PUB2
Anthony M. Brumby, Helena E. Richardson, Using Drosophila melanogaster to map human cancer pathways Nature Reviews Cancer. ,vol. 5, pp. 626- 639 ,(2005) , 10.1038/NRC1671
David Bilder, Min Li, Norbert Perrimon, Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science. ,vol. 289, pp. 113- 116 ,(2000) , 10.1126/SCIENCE.289.5476.113
Nicola A Grzeschik, Linda M Parsons, Helena Richardson, Lgl, the SWH pathway and tumorigenesis It's a matter of context & competition! Cell Cycle. ,vol. 9, pp. 3202- 3212 ,(2010) , 10.4161/CC.9.16.12633
Stefania Cocco, Alessandra Leone, Michela Piezzo, Roberta Caputo, Vincenzo Di Lauro, Francesca Di Rella, Giuseppina Fusco, Monica Capozzi, Germira di Gioia, Alfredo Budillon, Michelino De Laurentiis, Targeting autophagy in breast cancer World journal of clinical oncology. ,vol. 5, pp. 224- 240 ,(2014) , 10.5306/WJCO.V5.I3.224
Guy Tanentzapf, Ulrich Tepass, Interactions between the crumbs , lethal giant larvae and bazooka pathways in epithelial polarization Nature Cell Biology. ,vol. 5, pp. 46- 52 ,(2003) , 10.1038/NCB896