Sympathetic nervous system plays a major role in acute cold/restraint stress inhibition of host resistance to Listeria monocytogenes.

摘要: BALB/c mice exposed to acute cold/restraint stress (ACRS) had significantly lower host resistance Listeria monocytogenes (LM) than controls. The hormones corticosterone (CORT) and norepinephrine (NE), which are known modulate immune responses, were evaluated as the cause of decline in defense. involvement CORT NE was investigated by pretreating with synthesis inhibitor metyrapone chemical sympathectomy drug 6-hydroxydopamine (6-OHDA), respectively. LM burdens spleen liver determined three days post-infection. 6-OHDA decreased burden both control stressed animals. also completely blocked effects observed spleens while only partially affecting liver. 6-OHDA-uptake desipramine aided confirmation that peripheral sympathetic adrenergic nerves depletion, rather direct action 6-OHDA, responsible for susceptibility LM. results suggest nervous system (SNS) postganglionic neurotransmitter plays a major role has significant tissue-dependent after ACRS. In contrast, metyrapone-treated animals further LM, suggesting potential protective effect Altogether, play an important stress-modulated is hormone involved ACRS-induced suppression resistance.