Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man
作者： E M Scott , A M Carter , P J Grant
关键词: Endocrinology 、 Leptin 、 Haplotype 、 Obesity 、 Insulin resistance 、 Type 2 Diabetes Mellitus 、 Internal medicine 、 Type 2 diabetes 、 Metabolic syndrome 、 CLOCK 、 Medicine
摘要: Accumulating evidence raises the hypothesis that dysregulation of intrinsic clock mechanisms are involved in development metabolic syndrome, type 2 diabetes mellitus and cardiovascular disease. The aim present study was to investigate relationship between three known common polymorphisms Clock gene features syndrome man. Genotype haplotype analysis carried out a cohort 537 individuals from 89 families characterized for inflammatory, atherothrombotic risk associated with insulin resistance. Heritability defined according International Diabetes Federation criteria, 0.40. Haplotype indicated haplotypes: CAT, TGT CGC (rs4864548-rs3736544-rs1801260) frequencies 31, 33 28%, respectively. less prevalent subjects (P=0.0015) lower waist circumference (P=0.007), hip (P=0.023), body mass index (P=0.043) leptin levels (P=0.028). CAT significantly presence (P=0.020). These findings suggest may be protective obesity support genetic variation play role
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