Biomimetic models to examine microenvironmental regulation of glioblastoma stem cells

摘要: Glioblastoma multiforme (GBM), a malignant brain tumor, is the deadliest form of human cancer with low survival rates because its highly invasive nature. In recent years, there has been growing appreciation for role that glioblastoma stem cells (GSCs) play during tumorigenesis and tumor recurrence GBM. GSCs are specialized subset GBM cell-like features contribute to initiation therapeutic resistance. Thus, enhance efficiency improve survival, targeting their microenvironmental niche appears be promising approach. To develop this approach, understanding GSC-microenvironment interactions crucial. This review discusses various biomimetic model systems understand impact biophysical, biochemical, cellular cues on GSC behaviors. These models include two-dimensional or matrix-free environment models, engineered biomaterial-based three-dimensional co-culture mouse rat in vivo models. have used study effects biophysical factors, modulation signaling pathways, extracellular matrix components, culture conditions phenotype. The advantages disadvantages these field research discussed.