Cigarette smoking and rheumatoid arthritis

摘要: Abstract Objectives: To examine and explore the potential relationships among following: incidence/severity of rheumatoid arthritis (RA), extra-articular manifestations RA, vascular disease, certain specific malignancies, p53 tumor suppressor gene, cigarette smoking. Methods: The medical literature was reviewed from 1985 to 2001 with assistance a MEDLINE search using key words smoking, protein p53, vasculitis, cancer, malignancies. A qualitative review performed after all articles were abstracted new information summarized. Results: Cigarette smoking has been increasingly shown in epidemiologic case-control studies be an important risk factor for both incidence severity especially seropositive men. Further, there is evidence downward trend RA observed decrease worldwide tobacco use overall improved mortality RA. association lung other cancers its link disease (including Buerger's disease) atherosclerosis appears secure. Mutations or alterations gene that regulates cell growth, have found cancers, smokers, patients Conclusions: undeniable pathogenesis many types, including possibility strong causal connection vasculitis. observations decreasing along secular trends diminished vasculitis manifestations, survival, points better outcome our patients. example may first step discovery additional links between environmental triggers phenotypic expression chronic illness. Semin Arthritis Rheum 31:146-159. Copyright © by W.B. Saunders Company