Chronic Psychological Stress Disrupted the Composition of the Murine Colonic Microbiota and Accelerated a Murine Model of Inflammatory Bowel Disease

摘要: The effect of psychological stress on the gastrointestinal microbiota is widely recognized. Chronic may be associated with increased disease activity in inflammatory bowel disease, but relationships among stress, microbiota, and severity colitis not yet fully understood. Here, we examined impact 12-week repeated water-avoidance two inbred strains T cell receptor alpha chain gene knockout mouse (background, BALB/c C57BL/6) by means next-generation sequencing bacterial 16S rRNA genes. In both strains, caused a loss microbial diversity stability. exposure to markedly altered composition colonic C57BL/6 mice, mice. relative abundance genus Clostridium, some members which produce toxin phospholipase C, was increased, weakly positively severity, suggesting that expansion specific populations indigenous pathogens involved exacerbation colitis. However, also found exacerbated mice relatively diverse even if their contained an expanded C-producing Clostridium population. Exposure chronic concentration free immunoglobulin A contents, related exacerbation. Together, these results suggest long-term induces dysbiosis immunodeficient strain-specific manner alteration diversity, pattern secretion tract, might play crucial role development stress-induced