The cellular myb oncogene is amplified, rearranged and activated in human glioblastoma cell lines
作者： C. Welter , W. Henn , B. Theisinger , H. Fischer , K.D. Zang
DOI: 10.1016/0304-3835(90)90077-B
关键词: Coding region 、 MYB 、 Gene 、 Gene duplication 、 Carcinogenesis 、 Biology 、 Oncogene 、 Cell culture 、 Molecular biology 、 Cancer research 、 Binding protein
摘要: The human c-myb gene which encodes a DNA binding protein and is rarely amplified in neoplastic cells was found to be altered four glioblastoma cell lines. It exists multiple copies 2 out of 4 cases studied. degree amplification as determined by densitometry about 10-fold, rearrangement within the coding region an enhanced activity were noted. observation oncogene lines presents first report this effect brain tumor cells.
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