Changes in the biaxial viscoelastic response of the urinary bladder following spinal cord injury.

摘要: In order to gain a deeper understanding of bladder function, it is necessary study the time-dependent response wall. The present evaluated and compared viscoelastic behaviors normal spinal cord injured (SCI) rat wall tissue using an established model planar biaxial stress relaxation tests. Bladders from spinalized (3 weeks) rats were subjected (either 25 or 100 kPa in each loading direction) rapidly (in 50 ms) subsequently allowed relax at constant stretch levels modified Kreb's solution absence calcium; with no smooth muscle tone) for 10,000 s. We observed slower therefore less SCI group group, which varied stress-level. These experimental results fitted (r2 > 0.98) reduced function. Furthermore, biochemical assays revealed that collagen content bladders was significantly (p < 0.05) lower by 43%, while elastin 0.001) higher 260% than bladders. suggest associated urologic functional changes induce profound remodeling, which, turn, provided structural basis alterations complex, mechanical behavior urinary study.