Rho kinase, a promising drug target for neurological disorders
作者： Bernhard K. Mueller , Helmut Mack , Nicole Teusch
DOI: 10.1038/NRD1719
关键词: Neurodegeneration 、 Anatomy 、 Neuroregeneration 、 Cancer research 、 Kinase 、 Rho-associated protein kinase 、 Biology 、 Central nervous system 、 Regeneration (biology) 、 Cell growth 、 Cell migration
摘要: Rho kinases (ROCKs), the first effectors to be described, are serine/threonine that important in fundamental processes of cell migration, proliferation and survival. Abnormal activation Rho/ROCK pathway has been observed various disorders central nervous system. Injury adult vertebrate brain spinal cord activates ROCKs, thereby inhibiting neurite growth sprouting. Inhibition ROCKs results accelerated regeneration enhanced functional recovery after spinal-cord injury mammals, inhibition also proved efficacious animal models stroke, inflammatory demyelinating diseases, Alzheimer's disease neuropathic pain. ROCK inhibitors therefore have potential for preventing neurodegeneration stimulating neuroregeneration neurological disorders.
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