Structure activity studies on somatostatin.
作者： D. SARANTAKIS , W. A. McKINLEY , I. JAUNAKAIS , D. CLARK , N. H. GRANT
DOI: 10.1111/J.1365-2265.1976.TB03835.X
关键词: Endocrinology 、 Plasma glucagon 、 Insulin 、 Plasma growth hormone 、 Growth hormone secretion 、 Internal medicine 、 Somatostatin 、 Biology
摘要: SUMMARY Seven synthetic analogues of somatostatin helped clarify structural requirements for suppression growth hormone secretion in rats. Size the ring is not critical; deletions serine-13, lysine-4 or asparagine-5 result peptides which retain an appreciable fraction activity. The analogue des-Ala1, Gly2, Asn5-somatostatin lowers plasma and insulin levels without affecting glucagon significantly.
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