Embryonic transplantation and ischemic memory deficit
作者： Tetsuya Masada , Toshifumi Itano , Mutsuo Fujisawa , Osamu Miyamoto , Masaaki Tokuda
DOI: 10.1016/S0168-0102(97)01158-9
关键词: Water maze 、 Anatomy 、 Transplantation 、 Dentate gyrus 、 Fetus 、 Biology 、 Hippocampus 、 Common carotid artery 、 Ischemia 、 Hippocampal formation
摘要: Transient forebrain ischemia is associated with selective neuronal vulnerability and persistent memory deficit. This study compares functional outcome morphological changes in rats subjected to post-ischemic CA1 or hilus/dentate gyrus region hippocampal fetal transplantation. Ischemia was produced by bilateral common carotid artery occlusion hypotension. Fetal neurons were transplanted into both sides of the dorsal hippocampus, 1 week post-ischemia. Four weeks post transplantation, underwent behavioral testing for 5 consecutive days using water maze trial. All animals perfusion fixed studies. Transplants hippocampus recovery, while grafts placed not. Similarly, morphologically similar pyramidal cell stained positive calbindin D28k. In contrast heterogeneous staining D28k not as robust. Post-ischemic transplantation effective improving function.
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