Chapter 13 Neural transplantation of horseradish peroxidase-labeled hippocampal cell suspensions in an experimental model of cerebral ischemia

摘要: Publisher Summary One of the major obstacles in assessing use neuronal transplants to replace cells that are lost because ischemia is inability identify and distinguish homotypically-transplanted from similar host brain. This chapter discusses horseradish peroxidase (HRP) label cell suspensions fetal rodent hippocampus were injected into hippocampi post-ischemic rats determine whether homotypically transplanted could be distinguished those host. When homotypic labeled with HRP, a required, which might help distinguishing transplant origin factor influencing survival appears placement within hippocampus. Whether minor differences histocompatibility between donor tissue combination cytotoxicity factors influence cellular an issue remains resolved. The suggests neural transplantation may feasible for treatment focal lesions produced during ischemia. Sufficient growth development occurred four vessel occlusion (VO) animals, justify further experiments this model.