Kuguacins F-S, cucurbitane triterpenoids from Momordica charantia
作者： Jian-Chao Chen , Wu-Qing Liu , Lu Lu , Ming-Hua Qiu , Yong-Tang Zheng
DOI: 10.1016/J.PHYTOCHEM.2008.10.011
关键词: Chemistry 、 Momordica 、 Terpenoid 、 Cucurbitaceae 、 Triterpenoid 、 Stereochemistry 、 Triterpene 、 Cucurbitane 、 Chemical structure 、 Medicinal plants
摘要: Chemical investigation of the vines and leaves Momordica charantia resulted in isolation fourteen cucurbitane triterpenoids, kuguacins F-S (1-14), including two pentanorcucurbitacins (6 7), one octanorcucurbitacin (8), trinorcucurbitacins (11 12), along with six known analogues. Their structures were elucidated on basis extensive spectroscopic single-crystal X-ray diffraction analyses. Compounds 1-14 exhibited weak anti-HIV-1 activities vitro. (C) 2008 Elsevier Ltd. All rights reserved.
cabdirect.org
elsevier.com
sci-hub.se 参考文章(22)
Z J Zhu, Z C Zhong, Z Y Luo, Z Y Xiao, Studies on the active constituents of Momordica charantia L Acta pharmaceutica Sinica. ,vol. 25, pp. 898- 903 ,(1990)
HIKARU OKABE, YUMI MIYAHARA, TATSUO YAMAUCHI, KAZUMOTO MIYAHARA, TOSHIO KAWASAKI, Studies on the constituents of Momordica charantia L. I. Isolation and characterization of momordicosides A and B, glycosides of a pentahydroxy-cucurbitane triterpene. Chemical & Pharmaceutical Bulletin. ,vol. 28, pp. 2753- 2762 ,(1980) , 10.1248/CPB.28.2753
HIKARU OKABE, YUMI MIYAHARA, TATSUO YAMAUCHI, Studies on the constituents of Momordica charantia L. IV. Characterization of the new cucurbitacin glycosides of the immature fruits. (2). Structures of the bitter glycosides, momordicosides K and L. Chemical & Pharmaceutical Bulletin. ,vol. 30, pp. 4334- 4340 ,(1982) , 10.1248/CPB.30.4334
Qing-Yan Li, Hu-Biao Chen, Zhen-Ming Liu, Bin Wang, Yu-Ying Zhao, Cucurbitane triterpenoids from Momordica charantia. Magnetic Resonance in Chemistry. ,vol. 45, pp. 451- 456 ,(2007) , 10.1002/MRC.1989
Majekodunmi O. Fatope, Yoshio Takeda, Hiroyasu Yamashita, Hikaru Okabe, Tatsuo Yamauchi, NEW CUCURBITANE TRITERPENOIDS FROM MOMORDICA CHARANTIA Journal of Natural Products. ,vol. 53, pp. 1491- 1497 ,(1990) , 10.1021/NP50072A014
Chi-I Chang, Chiy-Rong Chen, Yun-Wen Liao, Hsueh-Ling Cheng, Yo-Chia Chen, Chang-Hung Chou, None, Cucurbitane-type triterpenoids from Momordica charantia. Journal of Natural Products. ,vol. 69, pp. 1168- 1171 ,(2006) , 10.1021/NP068008V
Sabira Begum, Mansoor Ahmed, Bina S. Siddiqui, Abdullah Khan, Zafar S. Saify, Mohammed Arif, Triterpenes, A sterol and A monocyclic alcohol from Momordica charantia Phytochemistry. ,vol. 44, pp. 1313- 1320 ,(1997) , 10.1016/S0031-9422(96)00615-2
Hisashi Matsuda, Seikou Nakamura, Toshiyuki Murakami, Masayuki Yoshikawa, Structures of New Cucurbitane‐Type Triterpenes and Glycosides, Karavilagenins D and E, and Karavilosides VI, VII, VIII, IX, X, and XI, from the Fruit of Momordica charantia. ChemInform. ,vol. 38, ,(2007) , 10.1002/CHIN.200730164
Yumiko Kimura, Toshihiro Akihisa, Noriko Yuasa, Motohiko Ukiya, Takashi Suzuki, Masaharu Toriyama, Shigeyasu Motohashi, Harukuni Tokuda, Cucurbitane-Type Triterpenoids from the Fruit of Momordica charantia Journal of Natural Products. ,vol. 68, pp. 807- 809 ,(2005) , 10.1021/NP040218P
Jian-Chao Chen, Gao-Hong Zhang, Zhong-Quan Zhang, Ming-Hua Qiu, Yong-Tang Zheng, Liu-Meng Yang, Kai-Bei Yu, Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity. Journal of Natural Products. ,vol. 71, pp. 153- 155 ,(2008) , 10.1021/NP0704396