Comparison of immunoblots with neutralizing and complement fixing antibodies in experimental and natural cases of visna-maedi.
作者： E. G. Torfason , M. Gudnad�ttir , A. L�ve
DOI: 10.1007/BF01317137
关键词: Complement fixation test 、 Virology 、 Visna virus 、 Antibody 、 Antigen 、 Virus 、 Humoral immunity 、 Viral envelope 、 Glycoprotein 、 Biology
摘要: In this study the humoral antibody response in visna-maedi virus disease sheep during long-term infection was analyzed utilizing immunoblot assays, neutralization tests and complement fixation tests. assays antibodies to several specific protein bands were detected, both against viral envelope glycoproteins internal proteins of virus. The reaction pattern resembled that found HIV-1 humans, consistent with reported similar molecular weight major these two viruses. band compared fixing neutralizing through preclinical clinical course natural experimental cases visna-maedi. Of six identified as specific, threegag products majorenv glycoprotein appeared early infection, at a time antibodies. proteins, one presumably transmembrane other possibly agag precursor, delayed.
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