Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation.

摘要: Forebrain subventricular zone (SVZ) progenitor cells give rise to glia and olfactory bulb interneurons during early postnatal life in rats. We investigated the potential of SVZ alter their fate by transplanting them into a heterotypic neurogenic gliogenic environment-the cerebellum. Transplanted were examined 1 7 weeks 6 months post transplantation. progenitors populated cerebellum differentiated oligodendrocytes, cerebellar-specific Bergmann velate astrocytes, neurons. The transplanted that neurons maintained an interneuronal fate: they GABA-positive, expressed markers, such as calretinin, exhibited membrane properties are characteristic interneurons. However, lost expression transcription factors Tbr2 Dlx1, acquired cerebellar-like morphology. thus have adapt new environment integrate diverse regions, may be useful tool transplantation strategies.