Expression of cyclins E, A, and B, and prognosis in lymph node-negative breast cancer.
作者： Heidi Kühling , Per Alm , Håkan Olsson , Mårten Fernö , Bo Baldetorp
DOI: 10.1002/PATH.1322
关键词: Biology 、 Breast cancer 、 Pathology 、 Cell cycle 、 Cyclin A 、 Cyclin B 、 Oncology 、 Survival rate 、 Cyclin E 、 Cyclin 、 Internal medicine 、 Survival analysis
摘要: Unexpected outcomes in breast cancer demand a refinement of prognostic criteria. This study therefore investigated the relevance cyclin expression cohort 332 T1-T2 N0 infiltrating ductal carcinomas with long-term follow-up (median 99 months). By univariate analysis, tumour size, histopathological grade, hormone receptor content, E, B, and Ki-S5 (Ki-67) index significantly predicted disease-specific metastasis-free survival. Cyclin A did not achieve statistical significance. In multivariate both E [relative risk (RR) 2.01, p = 0.021] B (RR 1.85, 0.033) were selected as independent prognosticators survival when Ki-67 was omitted, but only associated 2.56, 0.006). When included covariate, lost its significance respect to remained significant for an analogous analysis including Ki-67, number concurrently overexpressed cyclins attain regarding leading predictor metastatic disease. It is concluded that combined overexpression may imply genetic instability enhancing potential, ultimately depends on proliferative activity cells.
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