Transspinal Direct Current Stimulation Produces Persistent Plasticity in Human Motor Pathways.

摘要: The spinal cord is an integration center for descending, ascending, and segmental neural signals. Noninvasive transspinal stimulation may thus constitute effective method concomitant modulation of local distal circuits. In this study, we established changes in cortical excitability input/output function corticospinal circuits before, at 0–15 30–45 minutes after cathodal, anodal, sham direct current (tsDCS) to the thoracic region healthy individuals. We found that intracortical inhibition was different among polarities, however remained unchanged over time. Intracortical facilitation increased cathodal anodal tsDCS delivered with subjects seated, decreased lying supine. Both excitability, yet larger persisted 30 minutes post only when Spinal reflex by not tsDCS. These be attributed altered spontaneous activity membrane potentials corticomotoneuronal cells involving similar mechanisms those mediating motor learning. Our findings indicate has ability concomitantly alter cortical, corticospinal, output humans.