Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Is Initiated in an Uncommitted Progenitor Cell
作者： J. Pérez-Losada , N. Gutiérrez-Cianca , I. Sánchez-García
DOI: 10.3109/10428190109099316
关键词: Cancer research 、 Immunology 、 Biology 、 Chromosomal translocation 、 ABL 、 Progenitor cell 、 breakpoint cluster region 、 Fusion protein 、 Chronic myelogenous leukemia 、 Chromosome 22 、 Induced pluripotent stem cell
摘要: BCR-ABL is a chimeric oncogene generated by translocation of sequences from the c-ABLgene on chromosome 9 into BCR gene 22. Alternative proteins, BCR-ABLp190 and BCR-ABLp210, are produced that characteristic chronic myelogenous leukemia (CML) acute lymphoblastic (Ph1-ALL) respectively. In CML, it evident transformation occurs at level pluripotent stem cells. However, Ph1-ALL has been thought to affect progenitor cells with lymphoid differentiation. Recently, demonstrated normal primitive cells, rather than committed target for leukemic in Ph1-ALL. this review, we discuss what known about relationship between specific oncogene, cell characteristics subsequent disease process causes. We also how information may be applied establishment new directions therapy.
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